Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism

Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP).CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which enco

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Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.

Human adenoid cystic carcinoma (ACC) is characterized by diffused invasion of the tumor into adjacent organs and early distant metastasis.Anoikis resistance and epithelial mesenchymal transition (EMT) are considered prerequisites for cancer cells to metastasize.Exploring the relationship between these processes and their underlying mechanism of act

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Ethanolic Media Effect on the Susceptibility to Stress Corrosion Cracking in an X-70 Microalloyed Steel with Different Aging Treatments

The objective of this research was to evaluate the stress corrosion cracking (SCC) of X-70 micro-alloyed steel in contact with bio-ethanol and E-50 gasohol.Environmental factors, including water (1%, 3% and 5%) and NaCl (10 mg/L and 32 mg/L), as FRESH MINT FOAMING HAND SOAP well as two aging treatments were studied.Experimental values were obtained

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